Sickle cell disease is a hereditary disease seen most often among people of African ancestry. Caused by mutations in one of the genes that encode the hemoglobin protein, the disease is inherited as an autosomal recessive trait. The mutation causes the red blood cells to take on an unusual sickle shape. Individuals affected by sickle cell disease are chronically anemic and experience significant damage to their heart, lungs, and kidneys. Courtesy: National Human Genome Research Institute
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